First-in-human study monitors respiration and heart rate via an ingestible pill
MORGANTOWN, W.Va. – In a potential breakthrough for those suffering with opioid use disorder (OUD), the West Virginia University Rockefeller Neuroscience Institute (RNI) announced a first-in-human study using an innovative smart pill technology to measure and monitor vital signs that can help identify early indications of an overdose. The promising results are featured as the cover story of the November issue of Device, a monthly journal publishing the applied research needed to make groundbreaking fundamental research into tomorrow’s cutting-edge technology.
In this study, 10 participants undergoing sleep studies at the WVU Medicine Sleep Evaluation Center swallowed a Celero Systems Vitals Monitoring Pill (VM Pill), a device the size of a vitamin capsule that contains wireless sensors. Once ingested, the pill temporarily resides in the gastrointestinal tract, detecting respiration, heart rate, temperature, and gastric motility from inside the patient’s body. The study demonstrated that the VM Pill was able to accurately detect when the participants’ breathing slowed or stopped.
“This technology has the potential to transform how we monitor vital signs in patients by having the capability to measure respiration, heart rate, and other key body functions from an ingestible pill in people’s natural environment outside of the clinic or the hospital,” Ali Rezai, M.D., executive chair of the RNI, said. “The results are encouraging and provide us with new capabilities to help those at risk for overdose.”
According to the Centers for Disease Control and Prevention (CDC), there were more than 100,000 overdose deaths in the U.S. alone in 2022, along with an estimated 800,000 nonfatal overdoses.
“Seeing first-in-human data is always exciting, but even more so when it advances a product that can save lives in the opioid epidemic,” Ben Pless, CEO and founder of Celero Systems, RNI’s partner in the study, said. “We are fortunate to have the WVU Rockefeller Neuroscience Institute as our partner for this first in human study. RNI’s clinical and research expertise are world-class.”
In a follow-up study conducted at the WVU RNI, individuals with opioid use disorder ingested the VM Pill while in a residential addiction treatment setting.
“Initial data collected from the VM Pill study for addiction is promising,” James Mahoney, Ph.D., clinical neuropsychologist and director of addictions research at the RNI, said.
The data from that study will be made available in the coming months.
About the Rockefeller Neuroscience Institute (RNI)
The WVU Rockefeller Neuroscience Institute is a world-class multidisciplinary patient care, education, and research institute based in Morgantown, West Virginia. Home to more than 1,500 professionals, including 250 faculty members, the RNI provides neurological and mental health care for 275,000 patients annually. The RNI partners with academic and industry leaders to pioneer advances in brain health and therapeutics using innovative technologies. Our five departments are making tangible progress in combating public health challenges. ranging from addiction to Alzheimer’s. For more information about the WVU Rockefeller Neuroscience Institute, visit WVUMedicine.org/RNI.
About Celero Systems
Celero Systems is a Boston-based startup company spun out of Mass General Brigham Innovations based on intellectual property licensed from Brigham and Women’s Hospital and the Massachusetts Institute of Technology. The mission of the company is to develop ingestible capsules with extended residency in the gastrointestinal tract for digital health and automatic drug delivery. For more information about Celero Systems, visit CeleroSystems.com.