Genetic Evaluation Influences Treatment


Genetic breast cancer accounts for about 10 percent of all breast cancer cases. Of the known hereditary mutations that have been shown to cause breast cancer, BRCA (BReast CAncer) accounts for over 90 percent. There are two BRCA genes: BRCA 1, located on chromosome 17, and BRCA 2, located on chromosome 13.

For patients who are BRCA-positive, there are a variety of treatment and preventative measures that can be used against breast cancer. Initially, increased breast imaging allows physicians to keep a close eye on any suspicious lumps or masses. It may be beneficial for the patient to receive digital mammography as well as breast MRI, alternating the imaging every six months. Tamoxifen may also be prescribed for some BRCA 2-positive patients because 80 percent of these breast cancers will be estrogen receptor-positive.Genetics-Counseling

It has become increasingly popular for patients who are BRCA-positive to opt for bilateral mastectomies or salpingo-oopherectomies (BSO). These procedures can almost completely eliminate the risks of developing breast or ovarian cancer (90 percent with mastectomy and 96 percent with BSO). Adding to this trend is the significant advances that breast reconstruction has undergone in the last several years.


Appointments and Directions

855-WVU-CARE (855-988-2273)
1 Medical Center Drive
WVU Cancer Institute
Morgantown, WV 26506

The Referral Office schedules your “new patient” or first appointment. To schedule your first appointment, please call 877-427-2894 (toll free) or 304-598-4500 and ask for the referral office.

The MBRCC clinic has an automated appointment reminder system that calls you 24-48 hours before a scheduled appointment. Please be aware that calls may not be recognized by caller ID.

If you need to cancel or reschedule your first appointment, please call the Cancer Center and ask for the Referral Office at 304-598-4500.

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