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Elizabeth Engler-Chiurazzi, PhD – Research Assistant Professor; Director, WVU Rodent Behavior Core; Advisor, WVU Neuroscience Club

304.293.0503

PO Box 9229
BMRC room 119
WVU Health Sciences Center
Morgantown, WV 26506


Affiliations

Physiology, Pharmacology, & Neuroscience; Rockefeller Neuroscience Institute

Graduate Training

Arizona State University, Psychology (Behavioral Neuroscience)

Fellowship

Postdoctoral Fellow, Laboratory of Dr. James W. Simpkins, Brain Aging, Stroke, and Neurodegenerative Diseases, West Virginia University


Links

WVU Rodent Behavior Core

WVU Neuroscience Club

Research Assistant Professor; Director, WVU Rodent Behavior Core; Advisor, WVU Neuroscience Club

Research Interests

The research focus of Engler-Chiurazzi laboratory is to investigate how the central nervous and immune systems converge to impact brain function and health in the context of cognitive aging, brain injury and affective/mood disorders. To explore these complex interactions and identify/develop novel therapeutic targets or interventions to ease the burden of human disease, we employ a variety of techniques including the assessment of functional outcomes following experimental manipulations in a wide variety of behavioral domains (affective, cognitive, nociception, sensori/locomotion, substance use/abuse, etc) combined with subsequent evaluations of the neurophysiological and molecular biological correlates that underlie these behaviors. These efforts center around assessing immunological underpinnings of:

  1. Age-related Cognitive Decline
  2. Major Depressive Disorder
  3. Post-stroke Depression

Recent Publications

  1. Povroznik JP, Faith RE, Kesler MK, Ali F, Kosik J, Prince S,
    Engler-Chiurazzi EB (2017).
    Locomotor effects of a low-frequency fire alarm on C57BL/6 male mice.

    Lab Anim
    , 51(6): 647-651.
  2. Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW (2017).
    Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive
    and aging brain injury
    .
    Prog Neurobiol, 157:188-211. PMCID: PMC4985492
  3. Engler-Chiurazzi EB, Covey DF, Simpkins JW (2017).
    A novel mechanism of non-feminizing estrogens in neuroprotection.
    Exp Gerontol, 94:99-102. PMCID: PMC5415429
  4. Engler-Chiurazzi EB, Singh M, Simpkins JW (2016).
    From the 90’s to now: A brief historical perspective on more than two decades
    of estrogen neuroprotection
    .
    Brain Res, 1633:96-100. PMCID: PMC4762740
  5. Qian M,
    Engler-Chiurazzi EB, Lewis Se, Rath NP, Simpkins JW, Covey DF. (2016)
    Structure-activity studies of non-steroid analogues structurally-related to neuroprotective
    estrogens
    .
    Organic and Biomolecular Chemistry, 14(41): 9790-9805. PMCID: PMC5525543
  6. Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz
    TR, McBride CR, Yi J, Engels K, Simpkins JW (2016).
    Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior
    and cognition
    .
    J Toxicol Environ Health A, 79(11):447-52. PMCID: PMC4899177
  7. Doll DN,
    Engler-Chiurazzi EB, Lewis SE, Hu H, Kerr AE, Ren X, Simpkins JW (2015).
    Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke
    behavioral outcomes
    .
    Behav Brain Funct, 11(1):32. PMCID: PMC4604642
  8. Weitzner DS,
    Engler-Chiurazzi EB, Kotilinek LA, Ashe KH, Reed MN (2015).
    Morris Water Maze Test: Optimization for mouse strain and testing environment.
    J Vis Exp, (100):e52706. PMCID: PMC4545046

WVU Rockefeller Neuroscience Institute