Elizabeth Engler-Chiurazzi, PhD – Research Assistant Professor; Director, WVU Rodent Behavior Core; Advisor, WVU Neuroscience Club
PO Box 9229
BMRC room 119
WVU Health Sciences Center
Morgantown, WV 26506
Physiology, Pharmacology, & Neuroscience; Rockefeller Neuroscience Institute
Arizona State University, Psychology (Behavioral Neuroscience)
Postdoctoral Fellow, Laboratory of Dr. James W. Simpkins, Brain Aging, Stroke, and Neurodegenerative Diseases, West Virginia University
Research Assistant Professor; Director, WVU Rodent Behavior Core; Advisor, WVU Neuroscience Club
The research focus of Engler-Chiurazzi laboratory is to investigate how the central nervous and immune systems converge to impact brain function and health in the context of cognitive aging, brain injury and affective/mood disorders. To explore these complex interactions and identify/develop novel therapeutic targets or interventions to ease the burden of human disease, we employ a variety of techniques including the assessment of functional outcomes following experimental manipulations in a wide variety of behavioral domains (affective, cognitive, nociception, sensori/locomotion, substance use/abuse, etc) combined with subsequent evaluations of the neurophysiological and molecular biological correlates that underlie these behaviors. These efforts center around assessing immunological underpinnings of:
- Age-related Cognitive Decline
- Major Depressive Disorder
- Post-stroke Depression
- Povroznik JP, Faith RE, Kesler MK, Ali F, Kosik J, Prince S,
Engler-Chiurazzi EB (2017).
Locomotor effects of a low-frequency fire alarm on C57BL/6 male mice.
Lab Anim, 51(6): 647-651.
- Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW (2017).
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive
and aging brain injury.
Prog Neurobiol, 157:188-211. PMCID: PMC4985492
- Engler-Chiurazzi EB, Covey DF, Simpkins JW (2017).
A novel mechanism of non-feminizing estrogens in neuroprotection.
Exp Gerontol, 94:99-102. PMCID: PMC5415429
- Engler-Chiurazzi EB, Singh M, Simpkins JW (2016).
From the 90’s to now: A brief historical perspective on more than two decades
of estrogen neuroprotection.
Brain Res, 1633:96-100. PMCID: PMC4762740
- Qian M,
Engler-Chiurazzi EB, Lewis Se, Rath NP, Simpkins JW, Covey DF. (2016)
Structure-activity studies of non-steroid analogues structurally-related to neuroprotective
Organic and Biomolecular Chemistry, 14(41): 9790-9805. PMCID: PMC5525543
- Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz
TR, McBride CR, Yi J, Engels K, Simpkins JW (2016).
Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior
J Toxicol Environ Health A, 79(11):447-52. PMCID: PMC4899177
- Doll DN,
Engler-Chiurazzi EB, Lewis SE, Hu H, Kerr AE, Ren X, Simpkins JW (2015).
Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke
Behav Brain Funct, 11(1):32. PMCID: PMC4604642
- Weitzner DS,
Engler-Chiurazzi EB, Kotilinek LA, Ashe KH, Reed MN (2015).
Morris Water Maze Test: Optimization for mouse strain and testing environment.
J Vis Exp, (100):e52706. PMCID: PMC4545046