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Candice Brown, PhD – Assistant Professor

304.293.0589

1 Medical Center Drive
108 BMRC
PO Box 9128
Morgantown, WV 26506


Affiliations

Microbiology, Immunology, & Cell Biology; Emergency Medicine; Rockefeller Neuroscience Institute

Graduate Training

PhD in Genetics and Genomics, Duke University

Fellowship

Neuroscience and Endocrinology, University of California, Davis, and University of Washington

Assistant Professor

Lab website:

https://cmbrownlab.wordpress.com/

Dr. Brown is currently recruiting graduate students for her lab. If you are interested in joining her lab, please contact Dr. Brown directly.


Research Interests

The long-term research objective of my laboratory is to understand the neuroendocrine and neuroimmune mechanisms that control brain endothelial cell and blood-brain barrier responses to systemic inflammation. My research program addresses how prior acute systemic infections influence stroke severity and accelerate cognitive decline in mouse models of sepsis, ischemic stroke, and Alzheimer’s disease. Our studies will provide insights into how sex differences shape innate inflammatory responses that, in turn, enhance neurological dysfunction and promote neurodegenerative disease.

Research Topics

  1. Sex differences in brain responses to acute systemic inflammation in sepsis, stroke, and Alzheimer’s disease
  2. Mechanisms that preserve blood-brain barrier integrity and protect cerebral function in brain microvascular endothelial cells
  3. Brain and peripheral arginine metabolism in stroke and Alzheimer’s disease

 

Techniques and animal models include

Mouse models of acute and chronic inflammation

  • Sepsis – cecal ligation and puncture
  • schemic stroke – permanent and transient middle cerebral artery occlusion
  • Transgenic models of Alzheimer’s disease and vascular dementias

Cell culture

  • Brain endothelial cell primary cultures and hCMEC/D3 cells
  • Astrocyte and microglia primary cultures

Histology and microscopy

  • Alkaline phosphatase histochemistry and cerebral microvessel analysis
  • Stereology
  • Fluorescence and confocal microscopy

Animal behavior

Mass spectrometry

  • Metabolomics
  • Proteomics
  • LAESI: Laser ablation electrospray ionization

Lab Personnel + Collaborators

Lab Personnel

Sujung Jun, PhD

Research Associate

Wei Wang, MS

Laboratory Technician

Josh Wang

Research Technician

Medical Students

Brandon Neeley

MS1 2016 Summer Fellowship

Divine Nwafor

MS1 2016 Summer Fellowship

 

Current Undergraduates

Yamini Anantula

WVU Biology Honors Student, Class of 2017

Jorge Garcia

WVu Biology, Class of 2017

Patricia Doyle

WVU Biology, Class of 2018

Emily Hone

WVU Immunology and Medical Microbiology, Class of 2018

Pooja Warrier

2016 SURI Student, WVU Biomedical Engineering, Class of 2018

 

Lab Alumni

Sara Sine, WVU Biology, Class of 2016

Kaitlyn Runner, Neuroscience Graduate Student

 

Collaborators

Andrew Miller, MD – WVU School of Medicine, Department of Emergency Medicine

Carol A. Colton, PhD – Duke University Medical Center, Department of Neurology

Charles E. McCall, MD – Wake Forest School of Medicine, Department of Internal Medicine

Andy N. Hoofnagle, MD PhD – University of Washington, Department of Pathology

Protea Biosciences, Morgantown, WV

Open Positions: Eager, enthusiastic, and motivated students who would like to be a part of a collaborative neuroscience research team are welcome to contact Dr. Brown at any time to inquire about open positions in the laboratory.


Recent Publications

WVU Rockefeller Neuroscience Institute