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Bernard G Schreurs, PhD – Professor

304-293-0497

PO Box 9302
1024 BRNI Building
Morgantown, WV 26506


Affiliations

Physiology, Pharmacology, & Neuroscience; Rockefeller Neuroscience Institute

Graduate Training

PhD,  University of Iowa

Fellowship

Section on Neural Systems, NINDS, NIH

Research Interests

My research is in learning and memory, synaptic plasticity, and preclinical models of Alzheimer’s disease and posttraumatic stress disorder. The lab has been studying the neural basis of learning and memory using a number of model systems including the marine snail, Hermissenda, the rabbit eyelid/nictitating membrane preparation, and human eyelid conditioning. Studies have focused on revealing the behavioral laws and identifying the neural substrates of learning and memory as well as examining the synaptic plasticity that occurs at these substrates. We use classical conditioning as a behavioral paradigm and slice electrophysiology as a way of recording the changes that learning induces in the brain. We are currently using patch clamp recording and retrograde viral tack tracing to identify changes in specific neurons in the cerebellum involved in learning. We have developed an animal model of Alzheimer’s disease which can produce Alzheimer’s-like pathology using simple dietary manipulations. We also have an animal model of some aspects of posttraumatic stress disorder that has yielded insights into possible behavioral treatments for the disorder.

Research Topics

  1. Determining behavioral and pharmacological treatments for Posttraumatic Stress Disorder in a preclinical model.
  2. Developing and studying preclinical models of Alzheimer’s Disease induced by dietary manipulations.
  3. Antero- and retrograde polysynaptic viral track tracing and slice electrophysiology.

Lab Personnel and Collaborators

Lauren B. Burhans, Ph.D.
Research Associate
lburhans@brni.org
 
Roger Bell, B.S.
Senior Research Assistant
Sylwia W. Brooks, B.S.
MD/Ph.D. candidate
smrowka@brni.org
Carrie A. Smith-Bell, B.S.
Senior Research Assistant
Desheng Wang, MD, Ph.D.
Research Associate
dswang@brni.org

Publications

WVU Rockefeller Neuroscience Institute