The WVU Heart and Vascular Institute is a leader in cardiovascular care and research in West Virginia. Our patients have access to the most current procedures and treatments.

The experts at the WVU Heart and Vascular Institute conduct ongoing heart and vascular clinical trials and research studies.

 

Current Recruiting Studies                   

NCT02321514:  Early Feasibility Study of the Tendyne Mitral Valve System

The purpose of this study is to generate initial insights into the safety and performance of the Tendyne Mitral Valve System. The study includes adult patients with symptomatic mitral regurgitation who are not suitable candidates for conventional mitral valve repair or replacement. Follow-up evaluations will be conducted through two years post implantation.

Study Type: Interventional

Study Design: Single Group Assignment, Open Label

 

NCT02879448:  AMPLATZER™ Amulet™ Left Atrial Appendage Occluder Randomized Controlled Trial

The Amulet™ device will be evaluated for safety and efficacy by demonstrating its performance is non-inferior to the commercially available WATCHMAN® left atrial appendage closure device in patients with non-valvular atrial fibrillation. Patients who are eligible for the trial will be randomized to receive either the Amulet device or the WATCHMAN device and will be followed for five years after device implant.

Study Type: Interventional

Study Design: Randomized, Open Label

 

NCT02279888: CardioMEMS HF System Post Approval Study

The purpose of the CardioMEMS HF System Post Approval Study (PAS) is to evaluate the use of the CardioMEMS HF System in patients with NYHA class III heart failure in a commercial setting.

Study Population: Patients with NYHA class III heart failure

Study Design: Observational

 

NCT02554890: A Multicenter, Randomized, Double-blind, Double Dummy, Parallel Group, Active-controlled 8-week Study to Evaluate the Effect of Sacubitril/Valsartan (LCZ696) Versus Enalapril on Changes in NT-proBNP and Safety and Tolerability of In-hospital Initiation of LCZ696 Compared to Enalapril in HFrEF Patients Who Have Been Stabilized Following Hospitalization for Acute Decompensated Heart Failure (ADHF).

The purpose of this study is to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following hospitalization for acute decompensated heart failure (ADHF) and reduced ejection fraction (left ventricular ejection fraction (LVEF) ≤ 40%).

Study Type: Interventional

Study Design: Allocation: Randomized

 

For more information about these studies, contact Annina Guzek, RN, at 304-293-0615 or annina.guzek@wvumedicine.org.